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KMID : 1189420100230020109
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2010 Volume.23 No. 2 p.109 ~ p.124
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The Antiallergic Effects of Yeotaectonggi-tang (YTT) on the Mice Model with Allergic Rhinitis by Regulation of PPAR-γ
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Son Jung-Min
Hong Seung-Ug
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Abstract
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Objectives : The aim of this study is to investigate the antiallergic effects of YTT on allergic rhinitis by regulation of peroxisome proliferator-activated receptor gamma (PPAR-γ).
Methods : The thirty rats were divided into three groups : normal group, control (allergic rhinitis elicited) group, sample (Yeotaectonggi-tang treated after allergic rhinitis elicitation) group. To induce allergic rhinitis in control group and sample group, rats were sensitized intraperitoneally with 0.1% ovalbumin(OVA) solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin(OVA) solution 3 times at intervals of 2 days. After that time rats in sample group were oral administration treated by YTT for 7days. The change of the amounts of eosinophil, substance P, MIP-2, PPAR-γ, IL-4, iNOS were observed in each group. we used the statistical method of ANOVA test(p<0.05).
Results : The number of eosinophil in sample group noticeably decreased than control group. And the decrease of substance P and MIP-2 positive reaction were observed in mucosa. YTT inhibited IL-4 and iNOS production, mucus secretion, activation of mast cells and fibrosis remodeling by regulation of PPAR-γ activation.
Conclusion : According to the above results, it is considered that YTT mitigated mucosa damage on the
mice model with allergic rhinitis by regulation of PPAR-γ.
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KEYWORD
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allergic rhinitis, Yeotaectonggi-tang, eosinophil, substance P, MIP-2, PPAR-γ, IL-4, iNOS
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